Dataset Information

Intensive care drug therapy and its potential adverse effects on blood pressure and heart rate in critically ill children.

ABSTRACT:

Background

Owing to complex treatment, critically ill children may experience alterations in their vital parameters. We investigated whether such hemodynamic alterations were temporally and causally related to drug therapy.

Methods

In a university pediatric intensive care unit, we retrospectively analyzed hemodynamic alterations defined as values exceeding the limits set for heart rate (HR) and blood pressure (BP). For causality assessment, we used the World Health Organization-Uppsala Monitoring Center (WHO-UMC) system, which categorizes the probability of causality as "certain," "probable," "possible," and "unlikely."

Results

Of 315 analyzed patients with 43,200 drug prescriptions, 59.7% experienced at least one hemodynamic alteration; 39.0% were affected by increased HR, 19.0% by decreased HR, 18.1% by increased BP, and 16.2% by decreased BP. According to drug information databases, 83.9% of administered drugs potentially lead to hemodynamic alterations. Overall, 88.3% of the observed hemodynamic alterations had a temporal relation to the administration of drugs; in 80.2%, more than one drug was involved. Based on the WHO-UMC system, a drug was rated as a "probable" causing factor for only 1.4% of hemodynamic alterations. For the remaining alterations, the probability ratings were lower because of multiple potential causes, e.g., several drugs.

Conclusions

Critically ill children were frequently affected by hemodynamic alterations. The administration of drugs with potentially adverse effects on hemodynamic parameters is often temporally related to hemodynamic alterations. Hemodynamic alterations are often multifactorial, e.g., due to administering multiple drugs in rapid succession; thus, the influence of individual drugs cannot easily be captured with the WHO-UMC system.

SUBMITTER: Kiesel LM

PROVIDER: S-EPMC10423157 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Publications

Intensive care drug therapy and its potential adverse effects on blood pressure and heart rate in critically ill children.

Kiesel Lisa Marie LM Bertsche Astrid A Kiess Wieland W Siekmeyer Manuela M Bertsche Thilo T Neininger Martina Patrizia MP

World journal of pediatrics : WJP 20230228 9

<h4>Background</h4>Owing to complex treatment, critically ill children may experience alterations in their vital parameters. We investigated whether such hemodynamic alterations were temporally and causally related to drug therapy.<h4>Methods</h4>In a university pediatric intensive care unit, we retrospectively analyzed hemodynamic alterations defined as values exceeding the limits set for heart rate (HR) and blood pressure (BP). For causality assessment, we used the World Health Organization-Up ...[more]

PMID: 36854951

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Dataset Information

Intensive care drug therapy and its potential adverse effects on blood pressure and heart rate in critically ill children.

Background

Methods

Results

Conclusions

Publications

Intensive care drug therapy and its potential adverse effects on blood pressure and heart rate in critically ill children.

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