Automated LC-MS/MS: Ready for the clinical routine Laboratory?

ABSTRACT: Highlights • Automated LC-MS/MS demonstrated excellent analytical performance.• Automated LC-MS/MS is suitable for hospital and commercial medical laboratories.• Staff without technical expertise in LC-MS/MS can easily operate the automated LC-MS/MS.

Background

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a sensitive method with high specificity. However, its routine use in the clinical laboratory is hampered by its high complexity and lack of automation. Studies demonstrate excellent analytical performance using the first fully automated LC-MS/MS for 25-hydroxy vitamin D and immunosuppressant drugs (ISD) in hospital routine laboratories.

Objectives

Our objectives were (1) to verify the suitability of an automated LC-MS/MS in a commercial laboratory, which

SUBMITTER: Junger S 

PROVIDER: S-EPMC10423925 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature