Automated LC-MS/MS: Ready for the clinical routine Laboratory?

ABSTRACT:

Background

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a sensitive method with high specificity. However, its routine use in the clinical laboratory is hampered by its high complexity and lack of automation. Studies demonstrate excellent analytical performance using the first fully automated LC-MS/MS for 25-hydroxy vitamin D and immunosuppressant drugs (ISD) in hospital routine laboratories.

Objectives

Our objectives were (1) to verify the suitability of an automated LC-MS/MS in a commercial laboratory, which differs from the needs of hospital laboratories, and (2) examine its usability among operators with various professional backgrounds.

Methods

We assessed the analytical assay performance for vitamin D and the ISDs cyclosporine A and tacrolimus ov

SUBMITTER: Junger S 

PROVIDER: S-EPMC10423925 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature