Delineation of fatty acid metabolism in gastric cancer: Therapeutic implications.

ABSTRACT:

Background

The prognosis of gastric cancer is extremely poor. Metabolic reprogramming involving lipids has been associated with cancer occurrence and progression.

Aim

To illustrate fatty acid metabolic mechanisms in gastric cancer, detect core genes, develop a prognostic model, and provide treatment options.

Methods

Raw data from The Cancer Genome Atlas and Gene Expression Omnibus databases were collected and analyzed. Differentially expressed fatty acid metabolism genes were identified and incorporated into a risk model based on least absolute shrinkage and selection operator regression analysis. Then, patients from The Cancer Genome Atlas were assigned to high- and low-risk cohorts according to the mean value of the risk score as the threshold, which was verified in

SUBMITTER: Fu Y 

PROVIDER: S-EPMC10424035 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature