Risk of early- and late-onset Alzheimer disease and related dementia in adults with cerebral palsy.

ABSTRACT:

Aim

To examine the risk of Alzheimer disease and related dementia (ADRD) among adults with cerebral palsy (CP).

Method

Using administrative insurance claims data for 2007 to 2017 in the USA, we identified adults (45y or older) with a diagnosis of CP (n=5176). Adults without a diagnosis of CP were included as a typically developing comparison group (n=1 119 131). Using age, sex, ethnicity, other demographic variables, and a set of chronic morbidities, we propensity-matched individuals with and without CP (n=5038). Cox survival models were used to estimate ADRD risk within a 3-year follow up.

Results

The unadjusted incidence of ADRD was 9 and 2.4 times higher among cohorts of adults 45 to 64 years (1.8%) and 65 years and older (4.8%) with CP than the respective unmatche

SUBMITTER: Mahmoudi E 

PROVIDER: S-EPMC10424101 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature