Brain imaging signatures in amyotrophic lateral sclerosis: Correlation with peripheral motor degeneration.

ABSTRACT:

Objective

This study aimed to explore the clinical significance of brain imaging signatures in the context of clinical neurological deficits in association with upper and lower motor neuron degeneration in amyotrophic lateral sclerosis (ALS).

Methods

We performed brain MRI examinations to quantitatively evaluate (1) gray matter volume and (2) white matter tract fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD). Image-derived indices were correlated with (1) global neurological deficits of MRC muscle strength sum score, revised amyotrophic lateral sclerosis functional rating scale (ALSFRS-R), and forced vital capacity (FVC), and (2) focal scores of University of Pennsylvania Upper motor neuron score (Penn score) and the sum

SUBMITTER: Hsueh SJ 

PROVIDER: S-EPMC10424648 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature