Genome sequencing of 2000 canids by the Dog10K consortium advances the understanding of demography, genome function and architecture.

ABSTRACT:

Background

The international Dog10K project aims to sequence and analyze several thousand canine genomes. Incorporating 20 × data from 1987 individuals, including 1611 dogs (321 breeds), 309 village dogs, 63 wolves, and four coyotes, we identify genomic variation across the canid family, setting the stage for detailed studies of domestication, behavior, morphology, disease susceptibility, and genome architecture and function.

Results

We report the analysis of > 48 M single-nucleotide, indel, and structural variants spanning the autosomes, X chromosome, and mitochondria. We discover more than 75% of variation for 239 sampled breeds. Allele sharing analysis indicates that 94.9% of breeds form monophyletic clusters and 25 major clades. German Shepherd Dogs and related breeds sh

SUBMITTER: Meadows JRS 

PROVIDER: S-EPMC10426128 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature