The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers.

ABSTRACT:

Background

Common cancers develop through a multistep process often including inherited susceptibility. Collaboration among multiple institutions, and funding from multiple sources, has allowed the development of an inexpensive genotyping microarray, the OncoArray. The array includes a genome-wide backbone, comprising 230,000 SNPs tagging most common genetic variants, together with dense mapping of known susceptibility regions, rare variants from sequencing experiments, pharmacogenetic markers, and cancer-related traits.

Methods

The OncoArray can be genotyped using a novel technology developed by Illumina to facilitate efficient genotyping. The consortium developed standard approaches for selecting SNPs for study, for quality control of markers, and for ancestry analysis. Th

SUBMITTER: Amos CI 

PROVIDER: S-EPMC5224974 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature