Cellular and exosomal GPx1 are essential for controlling hydrogen peroxide balance and alleviating oxidative stress in hypoxic glioblastoma.

ABSTRACT: Tumor hypoxia promotes malignant progression and therapeutic resistance in glioblastoma partly by increasing the production of hydrogen peroxide (H₂O₂), a type of reactive oxygen species critical for cell metabolic responses due to its additional role as a second messenger. However, the catabolic pathways that prevent H₂O₂ overload and subsequent tumor cell damage in hypoxic glioblastoma remain unclear. Herein, we present a hypoxia-coordinated H₂O₂ regulatory mechanism whereby excess H₂O₂ in glioblastoma induced by hypoxia is diminished by glutathione peroxidase 1 (GPx1), an antioxidant enzyme detoxifying H₂O₂, via the binding of hypoxia-inducible factor-1α (HIF-1α) to GPx1 promote

SUBMITTER: Lei FJ 

PROVIDER: S-EPMC10428075 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature