Controlling the Release of Hydrogen Peroxide from Catechol-Based Adhesive Using Silica Nanoparticle.

ABSTRACT: Catechol-based bioadhesives generate hydrogen peroxide (H₂O₂) as a byproduct during the curing process. H₂O₂ can have both beneficial and deleterious effects on biological systems depending on its concentration. To control the amount of H₂O₂ released from catechol-containing polyethylene glycol-based adhesive (PEG-DA), adhesive was formulated with silica nanoparticles (SiNP) prepared with increased porosity and acid treatment to increase Si-OH surface content. These SiNP demonstrated increased surface area, which promoted interaction with catechol and resulted in increased cure rate, bulk mechanical properties and adhesive properties of PEG-DA. Most importantly, SiNP demonstrated a 50% reduction in the released H₂

SUBMITTER: Pinnaratip R 

PROVIDER: S-EPMC7580861 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature