Human Papillomavirus Intermittence and Risk Factors Associated With First Detections and Redetections in the Ludwig-McGill Cohort Study of Adult Women.

ABSTRACT:

Background

We assessed the incidence and risk factors for first detection and redetection with the same human papillomavirus (HPV) genotype, and prevalence of cytological lesions during HPV redetections.

Methods

The Ludwig-McGill cohort study followed women aged 18-60 years from São Paulo, Brazil in 1993-1997 for up to 10 years. Women provided cervical samples for cytology testing and HPV DNA testing at each visit. A redetection was defined as a recurring genotype-specific HPV positive result after 1 or more intervening negative visits. Predictors of genotype-specific redetection were assessed using adjusted hazard ratios (aHR) with Cox regression modeling.

Results

In total, 2184 women contributed 2368 incident HPV genotype-specific first detections and 308 genotype-s

SUBMITTER: Malagon T 

PROVIDER: S-EPMC10428201 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature