Unknown

Dataset Information

0

Comparing the evolutionary dynamics of predominant SARS-CoV-2 virus lineages co-circulating in Mexico.


ABSTRACT: Over 200 different SARS-CoV-2 lineages have been observed in Mexico by November 2021. To investigate lineage replacement dynamics, we applied a phylodynamic approach and explored the evolutionary trajectories of five dominant lineages that circulated during the first year of local transmission. For most lineages, peaks in sampling frequencies coincided with different epidemiological waves of infection in Mexico. Lineages B.1.1.222 and B.1.1.519 exhibited similar dynamics, constituting clades that likely originated in Mexico and persisted for >12 months. Lineages B.1.1.7, P.1 and B.1.617.2 also displayed similar dynamics, characterized by multiple introduction events leading to a few successful extended local transmission chains that persisted for several months. For the largest B.1.617.2 clades, we further explored viral lineage movements across Mexico. Many clades were located within the south region of the country, suggesting that this area played a key role in the spread of SARS-CoV-2 in Mexico.

SUBMITTER: Castelan-Sanchez HG 

PROVIDER: S-EPMC10431917 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

Comparing the evolutionary dynamics of predominant SARS-CoV-2 virus lineages co-circulating in Mexico.

Castelán-Sánchez Hugo G HG   Delaye Luis L   Inward Rhys P D RPD   Dellicour Simon S   Gutierrez Bernardo B   Martinez de la Vina Natalia N   Boukadida Celia C   Pybus Oliver G OG   de Anda Jáuregui Guillermo G   Guzmán Plinio P   Flores-Garrido Marisol M   Fontanelli Óscar Ó   Hernández Rosales Maribel M   Meneses Amilcar A   Olmedo-Alvarez Gabriela G   Herrera-Estrella Alfredo Heriberto AH   Sánchez-Flores Alejandro A   Muñoz-Medina José Esteban JE   Comas-García Andreu A   Gómez-Gil Bruno B   Zárate Selene S   Taboada Blanca B   López Susana S   Arias Carlos F CF   Kraemer Moritz U G MUG   Lazcano Antonio A   Escalera Zamudio Marina M  

eLife 20230727


Over 200 different SARS-CoV-2 lineages have been observed in Mexico by November 2021. To investigate lineage replacement dynamics, we applied a phylodynamic approach and explored the evolutionary trajectories of five dominant lineages that circulated during the first year of local transmission. For most lineages, peaks in sampling frequencies coincided with different epidemiological waves of infection in Mexico. Lineages B.1.1.222 and B.1.1.519 exhibited similar dynamics, constituting clades tha  ...[more]

Similar Datasets

| S-EPMC9330581 | biostudies-literature
| S-EPMC9294468 | biostudies-literature
| S-EPMC8142660 | biostudies-literature
| S-EPMC8817759 | biostudies-literature
| S-EPMC6839445 | biostudies-literature
| S-EPMC9143188 | biostudies-literature
| S-EPMC11803630 | biostudies-literature
| S-EPMC8661738 | biostudies-literature
| S-EPMC7467077 | biostudies-literature
| S-EPMC8655444 | biostudies-literature