Population screening shows risk of inherited cancer and familial hypercholesterolemia in Oregon.

ABSTRACT: The Healthy Oregon Project (HOP) is a statewide effort that aims to build a large research repository and influence the health of Oregonians through providing no-cost genetic screening to participants for a next-generation sequencing 32-gene panel comprising genes related to inherited cancers and familial hypercholesterolemia. This type of unbiased population screening can detect at-risk individuals who may otherwise be missed by conventional medical approaches. However, challenges exist for this type of high-throughput testing in an academic setting, including developing a low-cost high-efficiency test and scaling up the clinical laboratory for processing large numbers of samples. Modifications to our academic clinical laboratory including efficient test design, robotics, and a streamline

SUBMITTER: O'Brien TD 

PROVIDER: S-EPMC10432140 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature