The effects of the NMDAR co-agonist D-serine on the structure and function of optic tectal neurons in the developing visual system.

ABSTRACT: The N-methyl-D-aspartate type glutamate receptor (NMDAR) is a molecular coincidence detector which converts correlated patterns of neuronal activity into cues for the structural and functional refinement of developing circuits in the brain. D-serine is an endogenous co-agonist of the NMDAR. We investigated the effects of potent enhancement of NMDAR-mediated currents by chronic administration of saturating levels of D-serine on the developing Xenopus retinotectal circuit. Chronic exposure to the NMDAR co-agonist D-serine resulted in structural and functional changes in the optic tectum. In immature tectal neurons, D-serine administration led to more compact and less dynamic tectal dendritic arbors, and increased synapse density. Calcium imaging to examine retinotopy of tectal neurons reveal

SUBMITTER: Chorghay Z 

PROVIDER: S-EPMC10435543 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature