Dataset Information

Is COVID-19 incriminated in new onset type 2 diabetes mellitus in Lebanese adults?

ABSTRACT:

Background

The effects of COVID-19 on the organism are still being investigated, especially after the transformation of this virus from a respiratory disease in its first appearance to a multi-organ disease that can affect nearly all systems and organs including the endocrinological system. The objective of the study was to find an association between COVID-19 infection and new onset type 2 diabetes in Lebanese adults.

Methods

A retrospective case-control study (2019-2022) included 200 subjects, 100 cases with new onset diabetes and 100 controls recruited from endocrinology clinics in rural and suburban located regions of Lebanon. Univariate and multivariate logistic regression were performed.

Results

Older age (aOR = 1.07; 95% CI 1.03-1.12), higher BMI (aOR = 1.32; 95% CI 1.17-1.48), having been infected with COVID-19 (aOR = 2.38; 95% CI 1.001-5.68) and having a family history of diabetes (aOR = 11.80; 95% CI 4.23-32.87) were significantly associated with higher odds of having new onset type 2 diabetes after adjusting for multiple risk factors.

Conclusion

In addition to the traditional risk factors for developing type 2 diabetes, a recent COVID-19 infection was associated with the new onset DM in our study. Subsequently screening for diabetes should be strongly recommended for patients post COVID-19 infection.

SUBMITTER: Jabbour RM

PROVIDER: S-EPMC10439538 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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Is COVID-19 incriminated in new onset type 2 diabetes mellitus in Lebanese adults?

Jabbour Rose Mary RM Hallit Souheil S Saliby Rita R Baydoun Abed El Karim AEK Nakhoul Nancy N

BMC research notes 20230818 1

<h4>Background</h4>The effects of COVID-19 on the organism are still being investigated, especially after the transformation of this virus from a respiratory disease in its first appearance to a multi-organ disease that can affect nearly all systems and organs including the endocrinological system. The objective of the study was to find an association between COVID-19 infection and new onset type 2 diabetes in Lebanese adults.<h4>Methods</h4>A retrospective case-control study (2019-2022) include ...[more]

PMID: 37596697

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Project description:ImportanceWhether COVID-19 contributes to youth-onset diabetes is controversial, and research in Asia is lacking.ObjectiveTo explore the incidence and severity of diabetes among youths during the COVID-19 pandemic in South Korea.Design, setting, and participantsThis cohort study used claims data for January 1, 2017, through February 28, 2022, from the National Health Insurance Service database in South Korea. The incidence of type 1 diabetes (T1D) and type 2 diabetes (T2D) in patients younger than 20 years during the pandemic was analyzed and compared with that during the prepandemic period. The study included incident cases of T1D identified by at least 2 diagnosis codes with at least 2 insulin prescriptions within 1 year and T2D identified by at least 2 diagnosis codes with at least 2 prescriptions of diabetes medication within 1 year. Analyses were performed between January 29 and September 2, 2024.ExposuresCOVID-19 pandemic and SARS-CoV-2 infection.Main outcomes and measuresThe primary outcome was incidence of T1D and T2D, and secondary outcomes included the rate of diabetic ketoacidosis (DKA) and association of new-onset diabetes with SARS-CoV-2 positivity.ResultsThe study included 2599 patients with T1D (mean [SD] age, 12.0 [4.8] years; 1235 [47.5%] male) and 11 040 patients with T2D (mean [SD] age, 16.0 [2.8] years; 6861 [62.1%] male). During the pandemic, the incidence rate ratios were 1.19 (95% CI, 1.10-1.29) for T1D and 1.41 (95% CI, 1.36-1.46) for T2D. The incidence rate of DKA at diagnosis increased during the first pandemic year compared with the prepandemic period (T1D, 42.8% [95% CI, 38.5%-47.0%] vs 31.3% [95% CI, 29.0%-33.7%], respectively; T2D, 6.0% [95% CI, 5.0%-7.1%] vs 2.9% [95% CI, 2.5%-3.3%], respectively) but returned to prepandemic levels in the second pandemic year (T1D, 34.5% [95% CI, 30.6%-38.5%]; T2D, 3.2% [95% CI, 2.6%-3.9%]). The hazard ratio for new-onset diabetes associated with SARS-CoV-2 positivity was 0.44 (95% CI, 0.17-1.13) for T1D and 1.08 (95% CI, 0.74-1.57) for T2D.Conclusions and relevanceThese findings suggest that the incidence and severity of T1D and T2D among South Korean youths increased during the COVID-19 pandemic. The cohort analysis does not support SARS-CoV-2 infection itself as being directly associated with incident diabetes.

Dataset Information

Is COVID-19 incriminated in new onset type 2 diabetes mellitus in Lebanese adults?

Background

Methods

Results

Conclusion

Publications

Is COVID-19 incriminated in new onset type 2 diabetes mellitus in Lebanese adults?

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