Zebrafish gonad mutant models reveal neuroendocrine mechanisms of brain sexual dimorphism and male mating behaviors of different brain regions.

ABSTRACT:

Background

Sexually dimorphic mating behaviors differ between sexes and involve gonadal hormones and possibly sexually dimorphic gene expression in the brain. However, the associations among the brain, gonad, and sexual behavior in teleosts are still unclear. Here, we utilized germ cells-free tdrd12 knockout (KO) zebrafish, and steroid synthesis enzyme cyp17a1-deficient zebrafish to investigate the differences and interplays in the brain-gonad-behavior axis, and the molecular control of brain dimorphism and male mating behaviors.

Methods

Tdrd12^+/-; cyp17a1^+/- double heterozygous parents were crossed to obtain tdrd12^-/-; cyp17a1^+/+ (tdrd12 KO), tdrd12^+/+; cyp17a1^-/- (cyp17a1 KO), and tdrd12^-/-; cyp17

SUBMITTER: Dai X 

PROVIDER: S-EPMC10440941 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature