Noninvasive In Vivo Thrombus Imaging in Patients With Ischemic Stroke or Transient Ischemic Attack-Brief Report.

ABSTRACT:

Background

¹⁸F-GP1 is a novel positron-emitting radiotracer that is highly specific for activated platelets and thrombus. In a proof-of-concept study, we aimed to determine its potential clinical application in establishing the role and origin of thrombus in ischemic stroke.

Methods

Eleven patients with recent ischemic stroke (n=9) or transient ischemic attack (n=2) underwent ¹⁸F-GP1 positron emission tomography and computed tomography angiography at a median of 11 (range, 2-21) days from symptom onset. ¹⁸F-GP1 uptake (maximum target-to-background ratio) was assessed in the carotid arteries and brain.

Results

¹⁸F-GP1 uptake was identified in 10 of 11 patients: 4 in the carotid arteries only, 3 in the brain only, and 3 in bot

SUBMITTER: Whittington B 

PROVIDER: S-EPMC10443628 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature