A surge in serum mucosal cytokines associated with seroconversion in children at risk for type 1 diabetes.

ABSTRACT:

Aims/introduction

Autoantibodies to pancreatic islet antigens identify young children at high risk of type 1 diabetes. On a background of genetic susceptibility, islet autoimmunity is thought to be driven by environmental factors, of which enteric viruses are prime candidates. We sought evidence for enteric pathology in children genetically at-risk for type 1 diabetes followed from birth who had developed islet autoantibodies ("seroconverted"), by measuring mucosa-associated cytokines in their sera.

Materials and methods

Sera were collected 3 monthly from birth from children with a first-degree type 1 diabetes relative, in the Environmental Determinants of Islet Autoimmunity (ENDIA) study. Children who seroconverted were matched for sex, age, and sample availability with ser

SUBMITTER: Harrison LC 

PROVIDER: S-EPMC10445231 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature