Tuberculin skin testing and QuantiFERON™-TB Gold Plus positivity among household contacts in Vietnam.

ABSTRACT:

Setting

TB infection (TBI) is diagnosed using the technique-dependent tuberculin skin test (TST) or costly, more accurate interferon-gamma release assays. The TST (⩾10 mm) threshold was indicated by previous research among household contacts in Vietnam, but routine implementation with a different tuberculin reagent showed unexpectedly low TST positivity.

Objective

TST (⩾5 mm and ⩾10 mm) results were compared to QuantiFERON™-TB Gold Plus (QFT) results in household contacts during community campaigns in 2020 and 2021.

Design

This was a cross-sectional multi-center implementation study.

Results

Among 1,330 household contacts in 2020, we found a TBI prevalence of 38.6% (QFT), similar to TST ⩾5 mm (37.4%) and higher than TST ⩾10 mm (13.1%). QFT+/TST+ was higher for

SUBMITTER: Innes AL 

PROVIDER: S-EPMC10446657 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature