Task-specific oscillatory synchronization of prefrontal cortex, nucleus reuniens, and hippocampus during working memory.

ABSTRACT: Working memory requires maintenance of and executive control over task-relevant information on a timescale of seconds. Spatial working memory depends on interactions between hippocampus, for the representation of space, and prefrontal cortex, for executive control. A monosynaptic hippocampal projection to the prefrontal cortex has been proposed to serve this interaction. However, connectivity and inactivation experiments indicate a critical role of the nucleus reuniens in hippocampal-prefrontal communication. We have investigated the dynamics of oscillatory coherence throughout the prefrontal-hippocampal-reuniens network in a touchscreen-based working memory task. We found that coherence at distinct frequencies evolved depending on phase and difficulty of the task. During choice, the reuni

SUBMITTER: de Mooij-van Malsen JG 

PROVIDER: S-EPMC10450413 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature