Cascade Amplified Plasmonics Molecular Biosensor for Sensitive Detection of Disease Biomarkers.

ABSTRACT: Recent advances in molecular technologies have provided various assay strategies for monitoring biomarkers, such as miRNAs for early detection of various diseases and cancers. However, there is still an urgent unmet need to develop practical and accurate miRNA analytical tools that could facilitate the incorporation of miRNA biomarkers into clinical practice and management. In this study, we demonstrate the feasibility of using a cascade amplification method, referred to as the "Cascade Amplification by Recycling Trigger Probe" (CARTP) strategy, to improve the detection sensitivity of the inverse Molecular Sentinel (iMS) nanobiosensor. The iMS nanobiosensor developed in our laboratory is a unique homogeneous multiplex bioassay technique based on surface-enhanced Raman scattering (SERS) det

SUBMITTER: Wang HN 

PROVIDER: S-EPMC10452163 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature