Circulating and Exosomal microRNA-33 in Childhood Obesity.

ABSTRACT:

Background

MicroRNA-33 may control a wide range of different metabolic functions.

Methods

This study aims to assess the miR-33a circulating profile in normal-weight (N = 20) and obese (O = 30) adolescents and to correlate its expression levels to their metabolic parameters. In a subset of subjects, we compared circulating miR-33a with exosomal miR-33a.

Results

Metabolic parameters were altered in O, with initial hyperinsulinemia. Circulating miR-33a was significantly higher in O than in N (p = 0.0002). Significant correlations between miR-33a and auxological and metabolic indices (Insulin p = 0.01; Cholesterol p = 0.01; LDL p = 0.01; HbA1c p = 0.01) were found. Splitting our population (O + N) into two groups, according to the median

SUBMITTER: Cabiati M 

PROVIDER: S-EPMC10452681 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature