Biologically Relevant Murine Models of Chronic Pseudomonas aeruginosa Respiratory Infection.

ABSTRACT: Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic pathogen and the leading cause of infection in patients with cystic fibrosis (CF). The ability of P. aeruginosa to evade host responses and develop into chronic infection causes significant morbidity and mortality. Several mouse models have been developed to study chronic respiratory infections induced by P. aeruginosa, with the bead agar model being the most widely used. However, this model has several limitations, including the requirement for surgical procedures and high mortality rates. Herein, we describe novel and adapted biologically relevant models of chronic lung infection caused by P. aeruginosa. Three methods are described: a clinical isolate infection model, utilising isolates obtained from p

SUBMITTER: Rodgers AM 

PROVIDER: S-EPMC10458525 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature