Dataset Information

Faecal biomarkers of neutrophil and eosinophil origin reflect the response to biological therapy and corticosteroids in patients with IBD.

ABSTRACT:

Background

Faecal calprotectin (FC) is a non-invasive tool for examining response to biologics in inflammatory bowel disease (IBD), but its performance in relation to other novel faecal markers of various cellular origins is unknown.

Methods

We performed a prospective multicentre cohort study and included patients with active IBD who provided a faecal sample at initiation of biological therapy. Levels of FC, myeloperoxidase (MPO), human neutrophil lipocalin (HNL), and eosinophil-derived neurotoxin (EDN) were analysed and related to clinical remission status at 3 months. Changes in levels of markers at 3 months were calculated and the impact of concomitant use of corticosteroids at baseline was estimated.

Results

In patients achieving clinical remission (n=27), a decrease in levels of FC (p=0.005), MPO (p<0.001), HNL (p<0.001) and EDN (p<0.001) was observed, whereas no significant decrease was seen in patients not achieving remission (n=39). There was a significant difference in the change in the level of MPO (p=0.01) and HNL (p=0.02) between patients achieving clinical remission compared with those who did not, but changes in FC and EDN could not differentiate between these groups. Patients with concomitant systemic corticosteroids at inclusion had lower levels of HNL (p=0.01) and EDN (p<0.001) at baseline, compared with patients without corticosteroids.

Conclusion

Faecal MPO, HNL, and EDN are all promising biomarkers for assessing the treatment outcome of biologics in patients with IBD. Faecal levels of EDN and HNL are significantly affected by corticosteroids indicating a greater sensitivity to the effects of corticosteroids compared with FC and MPO.

SUBMITTER: Lundstrom ML

PROVIDER: S-EPMC10462075 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Publications

Fecal Biomarkers of Neutrophil and Eosinophil Origin Reflect the Response to Biological Therapy and Corticosteroids in Patients With Inflammatory Bowel Disease.

Ling Lundström Maria M Peterson Christer C Lampinen Maria M Hedin Charlotte R H CRH Keita Åsa V ÅV Kruse Robert R Magnusson Maria K MK Lindqvist Carl Mårten CM Repsilber Dirk D D'Amato Mauro M Hjortswang Henrik H Strid Hans H Rönnblom Anders A Söderholm Johan D JD Öhman Lena L Venge Per P Halfvarson Jonas J Carlson Marie M

Clinical and translational gastroenterology 20230801 8

<h4>Introduction</h4>Fecal calprotectin (FC) is a noninvasive tool for examining response to biologics in inflammatory bowel disease (IBD), but its performance in relation to other novel fecal markers of various cellular origins is unknown.<h4>Methods</h4>We performed a prospective multicenter cohort study and included patients with active IBD who provided a fecal sample at initiation of biological therapy. Levels of FC, myeloperoxidase (MPO), human neutrophil lipocalin (HNL), and eosinophil-der ...[more]

PMID: 37256716

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