Microbiome remodeling through bacterial competition and host behavior enables rapid adaptation to environmental toxins.

ABSTRACT: Human activity is altering the environment in a rapid pace, challenging the adaptive capacities of genetic variation within animal populations. Animals also harbor extensive gut microbiomes, which play diverse roles in host health and fitness and may help expanding host capabilities. The unprecedented scale of human usage of xenobiotics and contamination with environmental toxins describes one challenge against which bacteria with their immense biochemical diversity would be useful, by increasing detoxification capacities. To explore the potential of bacteria-assisted rapid adaptation, we used Caenorhabditis elegans worms harboring a defined microbiome, and neomycin as a model toxin, harmful for the worm host and neutralized to different extents by some microbiome members. Worms rai

SUBMITTER: Kim D 

PROVIDER: S-EPMC10462140 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature