Polygenic Risk Score Improves Prediction of Primary Open Angle Glaucoma Onset in the Ocular Hypertension Treatment Study.

ABSTRACT:

Objective or purpose

Primary open-angle glaucoma (POAG) is a highly heritable disease with 127 identified risk loci. Polygenic risks score (PRS) offers a measure of aggregate genetic burden. In this study, we assess whether PRS improves risk stratification in patients with ocular hypertension.

Design

A post-hoc analysis of the Ocular Hypertension Treatment Study (OHTS) data.

Setting participants and/or controls

1636 participants were followed from 1994 to 2020 across 22 sites. The PRS was computed for 1009 OHTS participants using summary statistics from largest cross-ancestry POAG metanalysis with weights trained using 8,813,496 variants from 488,395 participants in the UK Biobank.

Methods interventions or testing

Survival regression analysis, with endpoint as

SUBMITTER: Singh RK 

PROVIDER: S-EPMC10462203 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature