The relationship between longer leukocyte telomeres and dNCR in non-cardiac surgery patients: a retrospective analysis.

ABSTRACT:

Background

Cognitive decline following surgery is a common concern among elderly individuals. Leukocyte telomere length (LTL) can be assessed as a biological clock connected to an individual lifespan. However, the mechanisms causing this inference are still not fully understood. As a result of this, LTL has the potential to be useful as an aging-related biomarker for assessing delayed neurocognitive recovery (dNCR) and related diseases.

Methods

For this study, 196 individuals over 60 who were scheduled due to major non-cardiac surgical operations attended neuropsychological testing before surgery, followed by additional testing one week later. The finding of dNCR was based on a measured Z-score ≤ -1.96 on two or more separate tests. The frequency of dNCR was presented as the

SUBMITTER: Liu C 

PROVIDER: S-EPMC10463441 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature