Maintenance of adult stem cells from human minor salivary glands via the Wnt signaling pathway.

ABSTRACT:

Background

Xerostomia is a salivary gland dysfunction that negatively impacts the life quality of patients; however, there is no effective treatment for xerostomia. Bioengineered organs, generated using stem cells obtained from newborn salivary glands and ligated injury models, are a new organ transplantation strategy that could be feasible for xerostomia treatment. Reconstruction of salivary gland organoids by seed cells obtained from human minor salivary glands will offer theoretical fundaments and technology support for clinical application and organ regeneration research. Herein, we aimed to propose a new method for culturing and enriching adult human minor salivary gland stem cells in vitro in a three-dimensional (3D) environment via Wnt signaling activation.

Methods

Ob

SUBMITTER: Kang BK 

PROVIDER: S-EPMC10464143 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature