Minimal observed impact of HLA genotype on hospitalization and severity of SARS-CoV-2 infection.
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ABSTRACT:
SUBMITTER: Nguyen A
PROVIDER: S-EPMC10464832 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Publications
Minimal observed impact of HLA genotype on hospitalization and severity of SARS-CoV-2 infection.
Nguyen Austin A Yusufali Tasneem T Hollenbach Jill A JA Nellore Abhinav A Thompson Reid F RF
HLA 20220224 6
HLA is a critical component of the viral antigen presentation pathway. We investigated the relationship between the severity of SARS-CoV-2 disease and HLA type in 3235 individuals with confirmed SARS-CoV-2 infection. We found only the DPB1 locus to be associated with the binary outcome of whether an individual developed any COVID-19 symptoms. The number of peptides predicted to bind to an HLA allele had no significant relationship with disease severity both when stratifying individuals by ancest ...[more]
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