Marsdenia tenacissima enhances immune response of tumor infiltrating T lymphocytes to colorectal cancer.

ABSTRACT:

Introduction

Tumor-infiltrating T lymphocytes in the tumor microenvironment are critical factors influencing the prognosis and chemotherapy outcomes. As a Chinese herbal medicine, Marsdenia tenacissima extract (MTE) has been widely used to treat cancer in China. Its immunoregulatory effects on tumor-associated macrophages is well known, but whether it regulates tumor-infiltrating T-cell functions remains unclear.

Method

We collected 17 tumor samples from MTE-administered colorectal cancer patients, 13 of which showed upregulation of CD3+/CD8+ tumor-infiltrating T cells. Further in vitro and in vivo experiments were performed to investigate the regulatory effects of MTE on tumor-infiltrating T cells and immune escape of tumors.

Results

Under single and co

SUBMITTER: Yi B 

PROVIDER: S-EPMC10465246 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature