Sex differences in associations between creatinine and cystatin C-based kidney function measures with stroke and major bleeding.

ABSTRACT:

Purpose

We sought to explore whether adding kidney function biomarkers based on creatinine (eGFR_Cr), cystatin C (eGFR_Cys) or a combination of the two (eGFR_Cr-Cys) could improve risk stratification for stroke and major bleeding, and whether there were sex differences in any additive value of kidney function biomarkers.

Method

We included participants from the UK Biobank who had not had a previous ischaemic or haemorrhagic stroke or major bleeding episode, and who had kidney function measures available at baseline. Cause-specific Cox proportional hazards models tested associations between eGFR_Cr, eGFR_Cys and eGFR_Cr-Cys (mL/min/1.73 m²) with ischaemic and haemorrhagic stroke, major bleeding (gastrointe

SUBMITTER: Lees JS 

PROVIDER: S-EPMC10465308 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature