Influence of electric field, blood velocity, and pharmacokinetics on electrochemotherapy efficiency.

ABSTRACT: The convective delivery of chemotherapeutic drugs in cancerous tissues is directly proportional to the blood perfusion rate, which in turns can be transiently reduced by the application of high-voltage and short-duration electric pulses due to vessel vasoconstriction. However, electric pulses can also increase vessel wall and cell membrane permeabilities, boosting the extravasation and cell internalization of drug. These opposite effects, as well as possible adverse impacts on the viability of tissues and endothelial cells, suggest the importance of conducting in silico studies about the influence of physical parameters involved in electric-mediated drug transport. In the present work, the global method of approximate particular solutions for axisymmetric domains, together with two solutio

SUBMITTER: Velez Salazar FM 

PROVIDER: S-EPMC10465711 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature