Genetic spectrum of CAKUT and risk factors for kidney failure: a pediatric multicenter cohort study.

ABSTRACT:

Background

Congenital anomalies of the kidney and urinary tracts (CAKUT) are the leading cause of kidney failure in children with phenotypic and genotypic heterogeneity. Our objective was to describe the genetic spectrum and identify the risk factors for kidney failure in children with CAKUT.

Methods

Clinical and genetic data were derived from a multicenter network (Chinese Children Genetic Kidney Disease Database, CCGKDD) and the Chigene database. A total of 925 children with CAKUT who underwent genetic testing from 2014 to 2020 across China were studied. Data for a total of 584 children wereobtained from the CCGKDD, including longitudinal data regarding kidney function. The risk factors for kidney failure were determined by the Kaplan-Meier method and Cox proportional haza

SUBMITTER: Liu JL 

PROVIDER: S-EPMC10468753 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature