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Genetic risk factors for pediatric-onset multiple sclerosis.

ABSTRACT: BACKGROUND:Strong evidence supports the role of both genetic and environmental factors in pediatric-onset multiple sclerosis (POMS) etiology. OBJECTIVE:We comprehensively investigated the association between established major histocompatibility complex (MHC) and non-MHC adult multiple sclerosis (MS)-associated variants and susceptibility to POMS. METHODS:Cases with onset <18?years (n?=?569) and controls (n?=?16,251) were included from the United States and Sweden. Adjusted logistic regression and meta-analyses were performed for individual risk variants and a weighted genetic risk score (wGRS) for non-MHC variants. Results were compared to adult MS cases (n?=?7588). RESULTS:HLA-DRB1*15:01 was strongly associated with POMS (odds ratio (OR)meta?=?2.95, p?

SUBMITTER: Gianfrancesco MA 

PROVIDER: S-EPMC5878964 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Genetic risk factors for pediatric-onset multiple sclerosis.

Gianfrancesco Milena A MA   Stridh Pernilla P   Shao Xiaorong X   Rhead Brooke B   Graves Jennifer S JS   Chitnis Tanuja T   Waldman Amy A   Lotze Timothy T   Schreiner Teri T   Belman Anita A   Greenberg Benjamin B   Weinstock-Guttman Bianca B   Aaen Gregory G   Tillema Jan M JM   Hart Janace J   Caillier Stacy S   Ness Jayne J   Harris Yolanda Y   Rubin Jennifer J   Candee Meghan M   Krupp Lauren L   Gorman Mark M   Benson Leslie L   Rodriguez Moses M   Mar Soe S   Kahn Ilana I   Rose John J   Roalstad Shelly S   Casper T Charles TC   Shen Ling L   Quach Hong H   Quach Diana D   Hillert Jan J   Hedstrom Anna A   Olsson Tomas T   Kockum Ingrid I   Alfredsson Lars L   Schaefer Catherine C   Barcellos Lisa F LF   Waubant Emmanuelle E  

Multiple sclerosis (Houndmills, Basingstoke, England) 20171005 14

<h4>Background</h4>Strong evidence supports the role of both genetic and environmental factors in pediatric-onset multiple sclerosis (POMS) etiology.<h4>Objective</h4>We comprehensively investigated the association between established major histocompatibility complex (MHC) and non-MHC adult multiple sclerosis (MS)-associated variants and susceptibility to POMS.<h4>Methods</h4>Cases with onset <18 years (<i>n</i> = 569) and controls (<i>n</i> = 16,251) were included from the United States and Swe  ...[more]

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