Genetic risk factors for pediatric-onset multiple sclerosis.

ABSTRACT:

Background

Strong evidence supports the role of both genetic and environmental factors in pediatric-onset multiple sclerosis (POMS) etiology.

Objective

We comprehensively investigated the association between established major histocompatibility complex (MHC) and non-MHC adult multiple sclerosis (MS)-associated variants and susceptibility to POMS.

Methods

Cases with onset <18 years (n = 569) and controls (n = 16,251) were included from the United States and Sweden. Adjusted logistic regression and meta-analyses were performed for individual risk variants and a weighted genetic risk score (wGRS) for non-MHC variants. Results were compared to adult MS cases (n = 7588).

Results

HLA-DRB1*15:01 was strongly associated with POMS (odds ratio

SUBMITTER: Gianfrancesco MA 

PROVIDER: S-EPMC5878964 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature