Mast cell activation may contribute to adverse health transitions in COVID-19 patients with frailty

ABSTRACT: ABSTRACT A prominent aspect of the post-coronavirus disease-2019 (post-COVID-19) era is long-COVID. Therefore, precise patient classification and exploration of the corresponding factors affecting long-COVID are crucial for tailored treatment strategies. Frailty is a common age-related clinical syndrome characterized by deteriorated physiological functions of multiple organ systems, which increases susceptibility to stressors. Herein, we performed an inclusion and exclusion analysis (definite COVID-19 infection diagnosis, clear underlying disease information, ≥60 years old, and repeated sampling of clinical cases) of 10,613 blood samples and identified frailty cases for further investigation. RNA-Seq data were used for differential gene expression and functional and pathway analyses. The r

SUBMITTER: Li X 

PROVIDER: S-EPMC10469413 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature