Age-related differences in the functional topography of the locus coeruleus and their implications for cognitive and affective functions.

ABSTRACT: The locus coeruleus (LC) is an important noradrenergic nucleus that has recently attracted a lot of attention because of its emerging role in cognitive and psychiatric disorders. Although previous histological studies have shown that the LC has heterogeneous connections and cellular features, no studies have yet assessed its functional topography in vivo, how this heterogeneity changes over aging, and whether it is associated with cognition and mood. Here, we employ a gradient-based approach to characterize the functional heterogeneity in the organization of the LC over aging using 3T resting-state fMRI in a population-based cohort aged from 18 to 88 years of age (Cambridge Centre for Ageing and Neuroscience cohort, n=618). We show that the LC exhibits a rostro-caudal functional gradient a

SUBMITTER: Vereb D 

PROVIDER: S-EPMC10471162 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature