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Blood virome of patients with traumatic sepsis.

ABSTRACT: Sepsis is one of the possible outcomes of severe trauma, and it poses a dire threat to human life, particularly in immunocompromised people. The most prevalent pathogens are bacteria and fungi, but viruses should not be overlooked. For viral metagenomic analysis, we collected blood samples from eight patients with post-traumatic sepsis before and seven days after treatment. The results demonstrated that Anellovirus predominated the viral community, followed by Siphoviridae and Myoviridae, and that the variations in viral community and viral load before and after treatment were not statistically significant. This study allows us to investigate methods for establishing NGS-based viral diagnostic instruments for detecting viral infections in the blood of sepsis patients so that antiviral therapy can be administered quickly.

SUBMITTER: Mao Q

PROVIDER: S-EPMC10472630 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Blood virome of patients with traumatic sepsis.

Mao Qingqing Q Liu Ying Y Zhang Ju J Li Wang W Zhang Wen W Zhou Chenglin C

Virology journal 20230901 1

Sepsis is one of the possible outcomes of severe trauma, and it poses a dire threat to human life, particularly in immunocompromised people. The most prevalent pathogens are bacteria and fungi, but viruses should not be overlooked. For viral metagenomic analysis, we collected blood samples from eight patients with post-traumatic sepsis before and seven days after treatment. The results demonstrated that Anellovirus predominated the viral community, followed by Siphoviridae and Myoviridae, and th ...[more]

PMID: 37658428

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