Ultra-high density electrodes improve detection, yield, and cell type identification in neuronal recordings.

ABSTRACT: To understand the neural basis of behavior, it is essential to sensitively and accurately measure neural activity at single neuron and single spike resolution. Extracellular electrophysiology delivers this, but it has biases in the neurons it detects and it imperfectly resolves their action potentials. To minimize these limitations, we developed a silicon probe with much smaller and denser recording sites than previous designs, called Neuropixels Ultra (NP Ultra). This device samples neuronal activity at ultra-high spatial density (~10 times higher than previous probes) with low noise levels, while trading off recording span. NP Ultra is effectively an implantable voltage-sensing camera that captures a planar image of a neuron's electrical field. We use a spike sorting algorithm opt

SUBMITTER: Ye Z 

PROVIDER: S-EPMC10473688 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature