HCINAP alleviates senescence by regulating MDM2 via p14ARF and the HDAC1/CoREST complex.

ABSTRACT: Cellular senescence is a major process affected by multiple signals and coordinated by a complex signal response network. Identification of novel regulators of cellular senescence and elucidation of their molecular mechanisms will aid in the discovery of new treatment strategies for aging-related diseases. In the present study, we identified human coilin-interacting nuclear ATPase protein (hCINAP) as a negative regulator of aging. Depletion of cCINAP significantly shortened the lifespan of Caenorhabditis elegans and accelerated primary cell aging. Moreover, mCINAP deletion markedly promoted organismal aging and stimulated senescence-associated secretory phenotype in the skeletal muscle and liver from mouse models of radiation-induced senescence. Mechanistically, hCINAP functions through re

SUBMITTER: Huang X 

PROVIDER: S-EPMC10476552 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature