Bifunctional MXene-Augmented Retinal Progenitor Cell Transplantation for Retinal Degeneration.

ABSTRACT: Retinal degeneration, characterized by the progressive loss of retinal neurons, is the leading cause of incurable visual impairment. Retinal progenitor cells (RPCs)-based transplantation can facilitate sight restoration, but the clinical efficacy of this process is compromised by the imprecise neurogenic differentiation of RPCs and undermining function of transplanted cells surrounded by severely oxidative retinal lesions. Here, it is shown that ultrathin niobium carbide (Nb₂ C) MXene enables performance enhancement of RPCs for retinal regeneration. Nb₂ C MXene with moderate photothermal effect markedly improves retinal neuronal differentiation of RPCs by activating intracellular signaling, in addition to the highly effective RPC protection by scavenging free radicals

SUBMITTER: Tang Z 

PROVIDER: S-EPMC10477897 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature