Transmitted drug resistance and transmission clusters among ART-naive HIV-1-infected individuals from 2019 to 2021 in Nanjing, China.

ABSTRACT:

Background

Transmitted drug resistance (TDR) is an increasingly prevalent problem worldwide, which will significantly compromise the effectiveness of HIV treatments. However, in Nanjing, China, there is still a dearth of research on the prevalence and transmission of TDR among ART-naïve HIV-1-infected individuals. This study aimed to understand the prevalence and transmission of TDR in Nanjing.

Methods

A total of 1,393 participants who were newly diagnosed with HIV-1 and had not received ART between January 2019 and December 2021 were enrolled in this study. HIV-1 pol gene sequence was obtained by viral RNA extraction and nested PCR amplification. Genotypes, TDR and transmission cluster analyses were conducted using phylogenetic tree, Stanford HIV database algorithm a

SUBMITTER: Xu Y 

PROVIDER: S-EPMC10478099 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature