High-resolution crystal structure of the Mu8.1 conotoxin from Conus mucronatus.

ABSTRACT: Marine cone snails produce a wealth of peptide toxins (conotoxins) that bind their molecular targets with high selectivity and potency. Therefore, conotoxins constitute valuable biomolecular tools with a variety of biomedical purposes. The Mu8.1 conotoxin from Conus mucronatus is the founding member of the newly identified saposin-like conotoxin class of conotoxins and has been shown to target Cav2.3, a voltage-gated calcium channel. Two crystal structures have recently been determined of Mu8.1 at 2.3 and 2.1 Å resolution. Here, a high-resolution crystal structure of Mu8.1 was determined at 1.67 Å resolution in the high-symmetry space group I4₁22. The asymmetric unit contained one molecule, with a symmetry-related molecule generating a dimer equivalent to that observed in the tw

SUBMITTER: Muller E 

PROVIDER: S-EPMC10478764 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature