Personalized cancer avatars for patients with thymic malignancies: A pilot study with circulating tumor cell-derived organoids.

ABSTRACT:

Background

Systemic therapy is the primary treatment for advanced thymic malignancies. However, there is an urgent need to improve clinical outcome. Personalized treatment based on predictive biomarkers is a potential approach to address this requirement. In this study, we aimed to show the correlation between drug sensitivity tests on CTCs-derived organoids and clinical response in patients with thymic malignancies. This approach carries the potential to create personalized cancer avatars and improve treatment outcome for patients.

Methods

We previously reported potential treatment outcome prediction with patient-derived organoids (cancer avatars) in patients with pancreatic ductal adenocarcinoma. To further investigate the feasibility of this approach in advanced thymic ma

SUBMITTER: Wu YH 

PROVIDER: S-EPMC10481139 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature