Synapsin autoantibodies during pregnancy are associated with fetal abnormalities.
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ABSTRACT:
SUBMITTER: Bunger I
PROVIDER: S-EPMC10483408 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
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Synapsin autoantibodies during pregnancy are associated with fetal abnormalities.
Bünger Isabel I Talucci Ivan I Kreye Jakob J Höltje Markus M Makridis Konstantin L KL Foverskov Rasmussen Helle H van Hoof Scott S Cordero-Gomez César C Ullrich Tim T Sedlin Eva E Kreissner Kai Oliver KO Hoffmann Christian C Milovanovic Dragomir D Turko Paul P Paul Friedemann F Meckies Jessica J Verlohren Stefan S Henrich Wolfgang W Chaoui Rabih R Maric Hans Michael HM Kaindl Angela M AM Prüss Harald H
Brain, behavior, & immunity - health 20230829
Anti-neuronal autoantibodies can be transplacentally transferred during pregnancy and may cause detrimental effects on fetal development. It is unclear whether autoantibodies against synapsin-I, one of the most abundant synaptic proteins, are associated with developmental abnormalities in humans. We recruited a cohort of 263 pregnant women and detected serum synapsin-I IgG autoantibodies in 13.3% using cell-based assays. Seropositivity was strongly associated with abnormalities of fetal developm ...[more]
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