Localization of oskar mRNA by agglomeration in ribonucleoprotein granules.

ABSTRACT: Localization of oskar mRNA to the posterior of the Drosophila oocyte is essential for abdominal patterning and germline development. oskar localization is a multi-step process involving temporally and mechanistically distinct transport modes. Numerous cis-acting elements and trans-acting factors have been identified that mediate earlier motor-dependent transport steps leading to an initial accumulation of oskar at the posterior. Little is known, however, about the requirements for the later localization phase, which depends on cytoplasmic flows and results in the accumulation of large oskar ribonucleoprotein granules, called founder granules, by the end of oogenesis. Using super-resolution microscopy, we show that founder granules are agglomerates of smaller oskar transport particles. In c

SUBMITTER: Eichler CE 

PROVIDER: S-EPMC10484445 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature