Mutational Landscape and Precision Medicine in Hepatocellular Carcinoma.

ABSTRACT: Hepatocellular carcinoma (HCC) is the fourth most common malignancy worldwide and exhibits a universal burden as the incidence of the disease continues to rise. In addition to curative-intent therapies such as liver resection and transplantation, locoregional and systemic therapy options also exist. However, existing treatments carry a dismal prognosis, often plagued with high recurrence and mortality. For this reason, understanding the tumor microenvironment and mutational pathophysiology has become the center of investigation for disease control. The use of precision medicine and genetic analysis can supplement current treatment modalities to promote individualized management of HCC. In the search for personalized medicine, tools such as next-generation sequencing have been used to ident

SUBMITTER: Gorji L 

PROVIDER: S-EPMC10487145 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature