Protein Disulfide Isomerase A3 (PDIA3): A Pharmacological Target in Glioblastoma?

ABSTRACT: The protein disulfide isomerase A3 (PDIA3) is directly or indirectly involved in various physiopathological processes and participates in cancer initiation, progression and chemosensitivity. However, little is known about its involvement in glioblastoma. To obtain specific information, we performed cellular experiments in the T98G and U-87 MG glioblastoma cell lines to evaluate the role of PDIA3. The loss of PDIA3 functions, either through inhibition or silencing, reduced glioblastoma cells spreading by triggering cytotoxic phenomena. PDIA3 inhibition led to a redistribution of PDIA3, resulting in the formation of protein aggregates visualized through immunofluorescence staining. Concurrently, cell cycle progression underwent arrest at the G₁/S checkpoint. After PDIA3 inhibition

SUBMITTER: Paglia G 

PROVIDER: S-EPMC10488224 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature