Rapid Chemical Profiling of Filipendula ulmaria Using CPC Fractionation, 2-D Mapping of ¹³C NMR Data, and High-Resolution LC-MS.

ABSTRACT: Filipendula ulmaria, commonly known as meadowsweet, is a wild herbaceous flowering plant that is widely distributed in Europe. A range of salicylic acid derivatives and flavonol glycosides have been previously associated with the antirheumatic and diuretic properties of F. ulmaria. In the present work, a hydroalcoholic extract from F. ulmaria aerial parts was extensively profiled using an efficient NMR-based dereplication strategy. The approach involves the fractionation of the crude extract by centrifugal partition chromatography (CPC), ¹³C NMR analysis of the fractions, 2D-cluster mapping of the entire NMR dataset, and, finally, structure elucidation using a natural metabolite database, validated by 2D NMR data interpretation and liquid chromatography coup

SUBMITTER: Pannakal ST 

PROVIDER: S-EPMC10489126 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature