Low RPMB indicates better disease-free survival of adjuvant radiotherapy after radical surgery in thymoma.

ABSTRACT:

Background

The current use of adjuvant radiotherapy in thymoma (THYM) following radical surgery is primarily based on clinical factors and is a subject of ongoing debate.

Methods

We developed a new biomarker, promotor methylation burden of Deoxyribonucleic acid repair genes (RPMB), to identify patients who may benefit from adjuvant radiotherapy after complete resection in THYM. RPMB quantitatively measures the promoter methylation level of Deoxyribonucleic acid (DNA) repair genes.

Results

The methylation profile of 124 patients and corresponding clinical data were retrieved from The Cancer Genome Atlas (TCGA) database. The methylation level of DNA repair genes (DRGs) was found to be significantly hypomethylated juxtaposed to other genes across the whole human genome (

SUBMITTER: An N 

PROVIDER: S-EPMC10492043 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature