Reduction of absolute monocyte counts is associated with the severity of preterm necrotizing enterocolitis.

ABSTRACT:

Objective

Necrotizing enterocolitis (NEC) is characterized by a rich infiltration of macrophages in the intestines, which is derived from monocytes in the blood. The authors aimed to explore the changing trend of absolute monocyte counts (AMC) over time in NEC infants and to verify whether the reduction of AMC correlates with the severity of NEC and whether it can be used to identify infants who need surgery.

Method

The authors collected the clinical data of 66 control and 222 NEC infants. The NEC infants were divided into medical NEC (M-NEC) and surgical NEC (S-NEC). The counting of monocyte and their percentage change were compared at the time of birth, before NEC (baseline), the onset of NEC and after NEC (recovery). In addition, the same comparison was made among stages

SUBMITTER: Wang Z 

PROVIDER: S-EPMC10492144 | biostudies-literature | 2023 Sep-Oct

REPOSITORIES: biostudies-literature