Genetic variants in key necroptosis regulators predict prognosis of non-small cell lung cancer after surgical resection.

ABSTRACT:

Background

Necroptosis is a regulated inflammatory cell death which plays a significant role in cancer development and progression. In this study, we evaluated whether genetic variants in key regulators of necroptosis may affect survival outcome of non-small cell lung cancer (NSCLC) patients after surgical resection.

Methods

A total of 674 patients who underwent curative surgery were included. Fifteen genetic variants in key regulators of necroptosis (RIPK1, RIPK3, and MLKL) were selected. The association of these variants with survival outcomes was evaluated.

Results

Two variants, RIPK1 rs17548629C > T and MLKL rs877375G > C, were associated with better overall survival and disease-free survival in multivariate analyses. When the patients were divided according to hi

SUBMITTER: Lee JH 

PROVIDER: S-EPMC10493482 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature