Dataset Information

Genetic variants in key necroptosis regulators predict prognosis of non-small cell lung cancer after surgical resection.

ABSTRACT:

Background

Necroptosis is a regulated inflammatory cell death which plays a significant role in cancer development and progression. In this study, we evaluated whether genetic variants in key regulators of necroptosis may affect survival outcome of non-small cell lung cancer (NSCLC) patients after surgical resection.

Methods

A total of 674 patients who underwent curative surgery were included. Fifteen genetic variants in key regulators of necroptosis (RIPK1, RIPK3, and MLKL) were selected. The association of these variants with survival outcomes was evaluated.

Results

Two variants, RIPK1 rs17548629C > T and MLKL rs877375G > C, were associated with better overall survival and disease-free survival in multivariate analyses. When the patients were divided according to histology, the associations were significant only in adenocarcinoma, but not in squamous cell carcinoma. RIPK1 rs17548629 C-to-T change was associated with significantly increased luciferase activity by modulating the binding of miR-642a. Promoter assays showed a significantly increased promoter activity in MLKL rs877375C allele compared to G allele. Consistently, the mRNA expression level of RIPK1 and MLKL showed significant positive correlation with RIPK1 rs17548629C-to-T and MLKL rs877375G-to-C changes.

Conclusion

Two genetic variants in key regulators in necroptosis, RIPK1 rs17548629C > T and MLKL rs877375G > C, may be used as biomarkers to predict survival outcomes in surgically resected NSCLC patients.

SUBMITTER: Lee JH

PROVIDER: S-EPMC10493482 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Genetic variants in key necroptosis regulators predict prognosis of non-small cell lung cancer after surgical resection.

Lee Jang Hyuck JH Park Ji Eun JE Hong Mi Jeong MJ Choi Jin Eun JE Kang Hyo-Gyoung HG Do Sook Kyung SK Lee Sunwoong S Jeong Ji Yun JY Shin Kyung Min KM Do Young Woo YW Lee Eung Bae EB Lee Won Kee WK Oh In-Jae IJ Kim Young-Chul YC Choi Sun Ha SH Lee Yong Hoon YH Seo Hyewon H Lee Jaehee J Cha Seung Ick SI Kim Chang Ho CH Yoo Seung Soo SS Lee Shin Yup SY Park Jae Yong JY

Thoracic cancer 20230730 26

<h4>Background</h4>Necroptosis is a regulated inflammatory cell death which plays a significant role in cancer development and progression. In this study, we evaluated whether genetic variants in key regulators of necroptosis may affect survival outcome of non-small cell lung cancer (NSCLC) patients after surgical resection.<h4>Methods</h4>A total of 674 patients who underwent curative surgery were included. Fifteen genetic variants in key regulators of necroptosis (RIPK1, RIPK3, and MLKL) were ...[more]

PMID: 37519036

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Dataset Information

Genetic variants in key necroptosis regulators predict prognosis of non-small cell lung cancer after surgical resection.

Background

Methods

Results

Conclusion

Publications

Genetic variants in key necroptosis regulators predict prognosis of non-small cell lung cancer after surgical resection.

Similar Datasets

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